产品货号：
Z39358
中文名称：
ZAP70抗体
英文名称：
Anti-ZAP70 Antibody (Clone#1484CT290.68.62)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ZAP70 Antibody (Clone#1484CT290.68.62) |
| 指标别名 | Tyrosine-protein kinase ZAP-70;70kDa zeta-chain associated protein;Syk-related tyrosine kinase;Zap70;Srk;Zap-70 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,FCM,IF |
| 基因名称 | Zap70 |
| 克隆号 | 1484CT290.68.62 |
| 抗体来源 | Mouse |
| 免疫原 | This Zap70 antibody is generated from a mouse immunized with a recombinant protein. |
| 计算分子量 | 70kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response.Regulates motility,adhesion and cytokine expression of mature T-cells,as well as thymocyte development.Contributes also to the development and activation of primary B-lymphocytes.When antigen presenting cells (APC) activate T-cell receptor (TCR),a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD3Z through ITAM motif at the plasma membrane.This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation.Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK.Subsequently,ZAP70 phosphorylates at least 2 essential adapter proteins:LAT and LCP2.In turn,a large number of signaling molecules are recruited and ultimately lead to lymphokine production,T-cell proliferation and differentiation.Furthermore,ZAP70 controls cytoskeleton modifications,adhesion and mobility of T-lymphocytes,thus ensuring correct delivery of effectors to the APC.ZAP70 is also required for TCR-CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2.Thus,ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface.During thymocyte development,ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative).Additionally,ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). |
| Uniprot ID | P43404 |
相关搜索：ZAP70抗体，ZAP70单抗，Anti-ZAP70 Antibody (Clone#1484CT290.68.62)